ABSTRACT
The present study aimed to investigate the efficacy of adenotonsillectomy (AT) for children with obstructive sleep apnea syndrome (OSAS) and the improvement of their cognitive function.Studies on cognitive performance of OSAS children treated with or without AT were identified by searching the Pubmed,EMBASE and Cochrane library.A meta-analysis was conducted to analyze the literature.The random-effects model was used to evaluate 11 eligible studies using an inverse-variance method.The neuropsychological test results of 4 cognitive domains (general intelligence,memory,attention-executive function and verbal ability) were obtained and analyzed.By comparison of cognitive function between OSAS children and healthy controls,the effect sizes of each domain were achieved as follows:general intelligence,-0.5 (P＜0.0001);memory,-0.18 (P=0.02);attention-executive function,-0.21 (P=0.002);and verbal ability,-0.48 (P=0.0006).The effect sizes of general intelligence,memory,attention-executive function,and verbal ability after AT compared to baseline level were-0.37 (P=0.008),-0.36 (P=0.0005),-0.02 (P=0.88),and-0.45 (P=0.009),respectively.Comparing the cognitive ability between OSAS children after AT and healthy controls showed that the effect sizes were-0.54 (P=0.0009),-0.24 (P=0.12),-0.17 (P=0.35),and-0.45 (P=0.009) in general intelligence,memory,attention-executive function,and verbal ability,respectively.Our results confirmed that OSAS children performed worse than healthy children in terms of the 4 cognitive domains investigated.After 6-12 months of observation,significant improvement in attention-executive function and verbal ability were found in OSAS children treated with AT compared to their baseline level;restoration of attention-executive function and memory were observed in OSAS children after AT in comparison to healthy controls.Further rigorous randomized controlled trials should be conducted to obtain definitive conclusions.
ABSTRACT
The purpose of this study was to investigate the existence and extent of cognitive impairment in adult diabetes mellitus (DM) patients with episodes of recurrent severe hypoglycemia,by using meta-analysis to synthesize data across studies.PubMed,EMBASE and Cochrane library search engines were used to identify studies on cognitive performance in DM patients with recurrent severe hypoglycemia.Random-effects meta-analysis was performed on seven eligible studies using an inverse-variance method.Effect sizes,which are the standardized differences between the experimental group and the control group,were calculated.Of the 853 studies,7 studies met the inclusion criteria.Compared with control subjects,the adult DM patients with episodes of recurrent severe hypoglycemia demonstrated a significantly lowered performance on memory in both types of DM patients,and poor performance of processing speed in type 2 DM patients.There was no significant difference between adult DM patients with and those without severe hypoglycemia in other cognitive domains such as general intelligence,executive function,processing speed and psychomotor efficiency.Our results seem to confirm the hypothesis that cognitive dysfunction is characterized by worse memory and processing speed in adult DM patients with a history of recurrent severe hypoglycemia,whereas general intelligence,executive function,and psychomotor efficiency are spared.
ABSTRACT
Objective·To investigate the potential value of serum miRNAs for early diagnosis of acute coronary syndrome (ACS). Methods·Blood samples were collected from 28 emergency patients with suspected ACS in 3 h after enrollment. Eighteen patients were finally diagnosed as ACS and ten as non-ACS according to the ACS guideline. The expression levels of cardiac miR-499 and myocardial injury related miR-652 were measured with qRT-PCR. At the same time levels of troponin I (cTnI) were monitored. Then the correlations between miRNAs and cTnI were analyzed. In addition, 95% reference range was established. Results·The expression levels of serum miRNAs increased in ACS patients within 3 h and serum miR-499 in the ACS patients was 9.2 times the amount in the non-ACS patients (P=0.009). Serum miR-499 (r=0.595, P=0.001) and miR-652 (r=0.579, P=0.001) levels both had positive correlations with cTnI. The area under the ROC curve (AUC) of serum miR-499 and miR-652 was 0.786 and 0.583, respectively. The sensitivity and specificity of miR-499 were 72.22% and 80.00%, respectively, while 72.22% and 60.00% for miR-652. The reference ranges of serum miR-499 and miR-652 were 0.001-2.723 and 0.122-9.660, respectively. Conclusion·Cardiac miR-499 in serum has potential to be a biomarker for early diagnosis of ACS.
ABSTRACT
Objective·To investigate the potential value of serum miRNAs for early diagnosis of acute coronary syndrome (ACS). Methods·Blood samples were collected from 28 emergency patients with suspected ACS in 3 h after enrollment. Eighteen patients were finally diagnosed as ACS and ten as non-ACS according to the ACS guideline. The expression levels of cardiac miR-499 and myocardial injury related miR-652 were measured with qRT-PCR. At the same time levels of troponin I (cTnI) were monitored. Then the correlations between miRNAs and cTnI were analyzed. In addition, 95% reference range was established. Results·The expression levels of serum miRNAs increased in ACS patients within 3 h and serum miR-499 in the ACS patients was 9.2 times the amount in the non-ACS patients (P=0.009). Serum miR-499 (r=0.595, P=0.001) and miR-652 (r=0.579, P=0.001) levels both had positive correlations with cTnI. The area under the ROC curve (AUC) of serum miR-499 and miR-652 was 0.786 and 0.583, respectively. The sensitivity and specificity of miR-499 were 72.22% and 80.00%, respectively, while 72.22% and 60.00% for miR-652. The reference ranges of serum miR-499 and miR-652 were 0.001-2.723 and 0.122-9.660, respectively. Conclusion·Cardiac miR-499 in serum has potential to be a biomarker for early diagnosis of ACS.